LLA

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Natalia Monroy Villalobos's picture

Leucemica linfocitica aguda

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Edad de presentación

1-10 años
39 años

CLASIFICACIÍN X OMS

Precursores de células B ->ABL/BRC...
Precursores de células T
Burkitt -> t(8;14), t(2;8), t(8;22)

CLASIFICACIÓN FAB

Por relación de núcleo y citoplasma
ALL 1, ALL 2, ALL3

CC

agudo (<2 semanas) con fatiga, palidez, sangrado e infecciones, fiebre, hepato/esplenomegalia, masas mediastinales, afección SNC

FACTORES PRONÓSTICOS

Mayor edad peor pronostico
FILADELFIA: 9:22
Leucos >50 mil
SNC
Respuesta tarda al Tx

DIAGNÓSTICO

AMO, FROTIS: BLASTOS
Citometría de flujo: diferenciar precursores
Punción lumbar para buscar afección de SNC

TX

HIPER CVAD
-A: CFM, VINCRISTINA, ADRIAMICINA, DEXA
-B: CITARABINA, MTX INTRATECAL

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