LMA

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Natalia Monroy Villalobos's picture

LMA generalidades

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Tipo y mutación más frecuente en MX de LMA

M2 T(8:21)

Mutación de M3

T(15:17)

CID

sobre expresión de anexina II, elastasa y liberación al activador de plasminogeno tisular endotelial

Laboratorios LMA

Leucos de 35-50 mil hasta 100 mil

COMPLICACIÓN DE LMA

Sx de lisis tumoral

Sx de lisis tumoral

Hipocalcemia, hiper K/uricemia/fosfatemia

TX lisis tumoral

Hiperhidratar
Alopurinol

DX de LMA

Frotis: Giemsa-Wright
AMO: cuerpos de Auer

TX

Todas: inducción 7+3, consolidación
M3: ATRA

ATRA
7+3

ATRA: acido retinoico, trioxido de arsénico
7+3: citarabina + antracicleno

Remisión completa

<5% blastos
PMN >1000
Plq >100mil
Sin trasfusiones

Mal pronóstico

FLT31TD
<60 años
DHL elevada
secundario a QTx
>100mil leucos

Itx trasplante de MO alogénico

< 60 años
Refractarias a Tx
Marcadores de mal pronóstico: FLT3-1TD

CC

○ Anemia (palidez, letargia, etc)
○ Trombocitopenia (petequias gingivorragia)
○ Neutropenia (infecciones recurrente)

Tipos que afectan leptomeninges

M4 y M5

Otros marcadores de buen pronóstico

I (16:61), T (8:21), T (15:17)

Marcadores de mejor pronóstico

NPM1
CEBPA

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