LMC

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Natalia Monroy Villalobos's picture

LEUCEMIA MIELOIDE CRÓNICA

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CROMOSOMA FILADELFIA

9:22

FASES, CUÁL ES MÁS COMÚN

CRÓNICA -> MÁS COMÚN
BLÁSTICA
ACELERADA

LABS

LEUCOCITOSIS >100 MIL CON DESVIACIÓN A LA IZQUIERDA, ANEMIA TROMBOCITOSIS

FASE BLÁSTICA

Anemia + trombocitopenia
FEIBRE, DIAFORESIS, DOLOR ÓSEO

CC MÁS FRECUENTE

ELEVACIÓN CELULAR ASINTOMATICA

DX:
Frotis
elección
Gold

Frotis: mieloblastos a neutrofilos maduros
Cariotipo: cromosoma filadelfia
Elección FISH
GOLD PCR de ALB/BRC

TX

trasplante alogénico
QTX: imatinib, desatinib

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